Exchange 2010 (after SP3): OWA error, exppw.dll, event ID 2280

I would suggest you perform the following steps to troubleshoot this issue:

  1. Remove the exppw.dll entry from applicationhost.config (c:\windows\system32\inetsrv\config)

Then registered the exppw.dll by following the below steps:

  1. IIS Manager -> Select the Server Name in the left Pane -> Open Modules in the middle pane
  2. Click on ‘Configure Native Modules’ in the right pane -> Click the button ‘Register’ -> Type the name as ‘exppw’
  3. Browse and select the path of above file as: c:\Programme Files\Microsoft\Exchange Server\V14\Client Access\OWA\Auth\exppw.dll

After registered:

  1. Made sure that the ‘exppw.dll’ is only present at OWA level and not at any of the top hierarchy
  2. Then ensured for this module in OWA (VDir), ‘Module Type’ is set to ‘Native’ and ‘Entry Type’ is ‘Local’
  3. Run IISreset /noforce

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